Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320562 | 0.85 | HDAC1 (0.61) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8324344 | 0.81 | HDAC8 (0.41) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8325018 | 0.80 | PKM (0.39) | ALDH1A1PKMSMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL11051532 | 0.80 | RNASEH1 (0.49) | ALDH1A1PKMSMN1; SMN2LMNAKMT2A | |
| SCHEMBL8326099 | 0.71 | HDAC3 (0.67) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8318920 | 0.70 | HDAC1 (0.61) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11051317 | 0.69 | TP53 (0.40) | ALDH1A1SMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8320186 | 0.68 | HDAC1 (0.48) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8327639 | 0.68 | HDAC3 (0.45) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8327644 | 0.68 | HDAC3 (0.47) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |