Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326099 | 0.80 | HDAC3 (0.67) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL7002587 | 0.77 | GAA (0.42) | KMT2AGAASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL8327644 | 0.71 | HDAC3 (0.47) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL5264712 | 0.71 | ALDH1A1 (0.38) | SMN1; SMN2PKMALDH1A1LMNAMAPK1 | |
| SCHEMBL6994153 | 0.69 | GAA (0.58) | GAASMN1; SMN2PKMGRIN1GRIN2B | |
| SCHEMBL8320537 | 0.68 | HDAC8 (0.42) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL6948812 | 0.68 | PKM (0.58) | KMT2AGAASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL8327639 | 0.68 | HDAC3 (0.45) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL18291869 | 0.68 | ALDH1A1 (0.38) | SMN1; SMN2PKMALDH1A1LMNAMAPK1 | |
| SCHEMBL2972100 | 0.68 | ALDH1A1 (0.38) | SMN1; SMN2PKMALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |