Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321319 | 0.84 | ITGB3 (0.51) | MAPTPOLBLMNAKMT2AMEN1 | |
| SCHEMBL1663555 | 0.84 | MAPT (0.55) | MAPTPOLBLMNAGAAKMT2A | |
| SCHEMBL8318988 | 0.83 | MAPT (0.57) | MAPTPOLBLMNAKMT2AMEN1 | |
| SCHEMBL8325472 | 0.80 | ITGB3 (0.47) | MAPTPOLBLMNAKMT2AMEN1 | |
| SCHEMBL8662466 | 0.80 | MAPT (0.61) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9409454 | 0.79 | MAPT (0.60) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| Pyridine SCHEMBL8631988 | 0.76 | SIRT2 (0.47) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7387799 | 0.75 | MAPT (0.48) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7387805 | 0.75 | MAPT (0.48) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL24891825 | 0.74 | RAB9A (0.64) | MAPTLMNAKMT2AMEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912175-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-09-08 | — | — | EP | disclosed |
| EP-0912175-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5854245-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-12-29 | — | — | US | disclosed |
| WO-1998000134-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-01-08 | — | — | WO | disclosed |