Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.46 |
| ▸ | MMP2 | P08253 | 19/20 | 0.46 |
| ▸ | MMP8 | P22894 | 16/20 | 0.46 |
| ▸ | MMP9 | P14780 | 12/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223521 | 0.92 | MMP13 (0.54) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8329108 | 0.90 | MMP13 (0.52) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6225293 | 0.79 | MMP13 (0.56) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6268548 | 0.79 | MMP13 (0.49) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6224271 | 0.78 | MMP13 (0.55) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6223522 | 0.78 | MMP13 (0.54) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL5919374 | 0.75 | MMP13 (0.48) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8334721 | 0.73 | MMP13 (0.50) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8325431 | 0.72 | MMP13 (0.47) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL5908513 | 0.71 | MMP8 (0.50) | MMP13MMP2MMP8MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043943-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |