Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.56 |
| ▸ | MMP2 | P08253 | 19/20 | 0.56 |
| ▸ | MMP8 | P22894 | 19/20 | 0.56 |
| ▸ | MMP9 | P14780 | 13/20 | 0.55 |
| ▸ | MMP1 | P03956 | 3/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 4/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224271 | 0.99 | MMP13 (0.55) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6223521 | 0.85 | MMP13 (0.54) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6223522 | 0.85 | MMP13 (0.54) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8329108 | 0.84 | MMP13 (0.52) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6268548 | 0.84 | MMP13 (0.49) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8334721 | 0.82 | MMP13 (0.50) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8325431 | 0.82 | MMP13 (0.47) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL5919374 | 0.81 | MMP13 (0.48) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL8321971 | 0.79 | MMP13 (0.46) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6205603 | 0.79 | MMP13 (0.49) | MMP13MMP2MMP8MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562928-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20050101641-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2005-05-12 | — | — | US | disclosed |
| US-6890928-B2 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION (US) | 2005-05-10 | — | — | US | disclosed |
| US-20040110805-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2004-06-10 | — | — | US | disclosed |
| WO-2004043943-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |
| US-6689794-B2 | SUPPRESSING MATRIX METALLOPROTEINASE AND/OR AGGRECANASE ACTIVITY | PHARMACIA CORPORATION | 2004-02-10 | — | — | US | disclosed |
| US-20040024024-A1 | Aromatic sulfone hydroxamates and their use as protease inhibitors | PHARMACIA CORPORATION | 2004-02-05 | — | — | US | disclosed |
| EP-1385836-A2 | AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2004-02-04 | — | — | EP | disclosed |
| US-20040010019-A1 | Aromatic sulfone hydroxamates and their use as protease inhibitors | PHARMACIA CORPORATION | 2004-01-15 | — | — | US | disclosed |
| WO-2002092588-A2 | AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110805-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | MMP1, MMP7, MMP3 | MMP13 7/4885MMP2 9/4885MMP8 33/4885 |
| US-20050101641-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | MMP1, MMP3, MMP7 | MMP13 8/4885MMP2 12/4885MMP8 31/4885 |
| US-20040010019-A1 | Aromatic sulfone hydroxamates and their use as protease inhibitors | MMP1, MMP3, MMP7 | MMP13 10/4885MMP2 7/4885MMP8 34/4885 |
| US-20040024024-A1 | Aromatic sulfone hydroxamates and their use as protease inhibitors | MMP1, MMP3, MMP7 | MMP13 10/4885MMP2 7/4885MMP8 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.