SCHEMBL8322255

SCHEMBL8322255

COc1cc(-c2nnn[nH]2)ccc1CCc1cc(Cl)ccc1OCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 6/20 0.43
ABCG2 Q9UNQ0 1/20 0.43
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
LMNA P02545 3/20 0.40
HTT P42858 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HTR1A P08908 1/20 0.40
DRD2 P14416 1/20 0.40
USP2 O75604 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
PTGER1 P34995 4/20 0.40
PDE4A P27815 1/20 0.40
PDE4B Q07343 1/20 0.40
PDE4C Q08493 1/20 0.40
PDE4D Q08499 1/20 0.40
MEN1 O00255 1/20 0.40
MAPK1 P28482 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8323370 0.90 ABCB1 (0.50) ABCB1ABCG2KDM4ELMNAHTT
SCHEMBL8322241 0.87 HTR1A (0.44) ABCB1ABCG2KDM4EALDH1A1LMNA
SCHEMBL8405902 0.87 HTR1A (0.44) ABCB1ABCG2KDM4EALDH1A1LMNA
SCHEMBL8325042 0.86 ABCB1 (0.46) ABCB1ABCG2KDM4EALDH1A1LMNA
SCHEMBL9234740 0.85 MTNR1A (0.40) ABCB1HTR1ADRD2PTGER1PDE4A
SCHEMBL8406776 0.79 ABCB1 (0.55) ABCB1ABCG2HTR1ADRD2
SCHEMBL1247768 0.79 TSHR (0.50) KDM4EALDH1A1LMNASMN1; SMN2USP2
SCHEMBL8321903 0.78 HTR1A (0.48) ABCB1ABCG2HTR1ADRD2PTGER1
SCHEMBL8408170 0.76 HTR1A (0.61) ABCB1ABCG2HTR1ADRD2PTGER1
SCHEMBL8320664 0.76 HTR1A (0.61) ABCB1ABCG2HTR1ADRD2PTGER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP claimed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO claimed
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP disclosed
US-5811459-A PAIN RELIEVERS ZENECA LIMITED (GB) 1998-09-22 US disclosed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP disclosed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO disclosed