Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478086 | 0.77 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10TDP1 | |
| SCHEMBL1537127 | 0.70 | KDM4E (0.39) | KDM4EGPR3MAPK1NPC1LMNA | |
| SCHEMBL976367 | 0.68 | KDM4E (0.40) | KDM4EGPR3ALDH1A1HSD17B10TDP1 | |
| SCHEMBL18576434 | 0.67 | KDM4E (0.47) | KDM4EGPR3ALDH1A1HSD17B10TDP1 | |
| SCHEMBL30343302 | 0.67 | KDM4E (0.39) | KDM4EGPR3TDP1 | |
| SCHEMBL9350114 | 0.67 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10TDP1 | |
| SCHEMBL1829666 | 0.67 | KDM4E (0.39) | KDM4EGPR3ALDH1A1HSD17B10TDP1 | |
| SCHEMBL28080700 | 0.66 | KDM4E (0.38) | KDM4EGPR3 | |
| SCHEMBL29374271 | 0.64 | ACHE (0.46) | KDM4EGPR3ALDH1A1HSD17B10TDP1 | |
| SCHEMBL8088682 | 0.64 | ACHE (0.46) | KDM4EGPR3ALDH1A1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | disclosed |