Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323711 | 0.91 | PTGER1 (0.65) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8674867 | 0.88 | MTNR1B (0.51) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8674865 | 0.82 | MTNR1A (0.49) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8329639 | 0.79 | PTGER1 (0.53) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL9650328 | 0.78 | NR4A1 (0.60) | KMT2A | |
| SCHEMBL8322379 | 0.78 | PTGER1 (0.52) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL13690613 | 0.78 | NPC1 (0.49) | KMT2A | |
| SCHEMBL8325238 | 0.77 | PTGER1 (0.69) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8325918 | 0.77 | MTNR1B (0.55) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8327256 | 0.77 | PTGER1 (0.72) | PTGER1PTGER4PTGER3PTGER2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |