Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.65 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.65 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.65 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322781 | 0.91 | PTGER1 (0.53) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8674865 | 0.86 | MTNR1A (0.49) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8325238 | 0.86 | PTGER1 (0.69) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8322025 | 0.85 | PTGER1 (0.67) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL9058067 | 0.83 | PTGER1 (0.70) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8674867 | 0.82 | MTNR1B (0.51) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL9058140 | 0.82 | PTGER1 (0.73) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8321346 | 0.82 | PTGER1 (0.77) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL9064469 | 0.81 | PTGER1 (0.65) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL9059843 | 0.80 | PTGER1 (0.64) | PTGER1PTGER4PTGER3PTGER2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |