Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | UBE2N | P61088 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16174128 | 0.83 | NR3C1 (0.54) | KMT2AIDEUBE2NSIGMAR1CTNNB1 | |
| SCHEMBL31332073 | 0.83 | NR3C1 (0.54) | KMT2AIDEUBE2NSIGMAR1CTNNB1 | |
| SCHEMBL1697045 | 0.80 | SIGMAR1 (0.64) | SIGMAR1TAAR1SLC18A2CYP2D6 | |
| SCHEMBL27394759 | 0.79 | KMT2A (0.64) | KMT2AIDEUBE2NSIGMAR1HRH4 | |
| SCHEMBL8325161 | 0.78 | SIGMAR1 (0.56) | KMT2AIDEUBE2NSIGMAR1HRH4 | |
| SCHEMBL7058293 | 0.76 | KMT2A (0.43) | KMT2AIDEUBE2NSIGMAR1CTNNB1 | |
| Dimethylamine SCHEMBL11571354 | 0.75 | CYP2C19 (0.50) | KMT2ASIGMAR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL31332121 | 0.75 | EPHX1 (0.61) | SIGMAR1HRH4CTNNB1TAAR1CYP1A2 | |
| SCHEMBL8326605 | 0.74 | CYP2D6 (0.50) | KMT2AIDEUBE2NSIGMAR1HRH4 | |
| SCHEMBL5171664 | 0.74 | MME (0.59) | KMT2AHRH4CTNNB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |