SCHEMBL8323150

SCHEMBL8323150

Clc1ccc(-c2ccc3c(c2)CCNC3)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ASIC3 Q9UHC3 6/20 0.78
PNMT P11086 3/20 0.62
HTR2A P28223 1/20 0.56
HTR2C P28335 1/20 0.56
HTR2B P41595 1/20 0.56
SLC2A1 P11166 2/20 0.52
DRD2 P14416 1/20 0.50
DRD3 P35462 1/20 0.50
MLNR O43193 1/20 0.49
CD274 Q9NZQ7 2/20 0.48
CD44 P16070 1/20 0.47
MAOB P27338 1/20 0.47
JAK2 O60674 1/20 0.46
NTRK1 P04629 1/20 0.46
MET P08581 1/20 0.46
FGFR1 P11362 1/20 0.46
PRKACA P17612 1/20 0.46
KDR P35968 1/20 0.46
MAP2K2 P36507 1/20 0.46
FLT3 P36888 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7807038 0.98 ASIC3 (0.76) ASIC3PNMTHTR2AHTR2CHTR2B
Hydrochloric Acid SCHEMBL7808608 0.86 ASIC3 (0.97) ASIC3PNMTHTR2AHTR2CHTR2B
SCHEMBL532012 0.85 PNMT (0.85) ASIC3PNMTHTR2AHTR2CHTR2B
SCHEMBL29543416 0.85 ASIC3 (0.56) ASIC3PNMTHTR2AHTR2CHTR2B
SCHEMBL6347388 0.84 ASIC3 (0.65) ASIC3PNMTDRD2DRD3CD274
Hydrochloric Acid SCHEMBL947776 0.83 PNMT (0.81) ASIC3PNMTHTR2AHTR2CHTR2B
SCHEMBL28274279 0.82 ASIC3 (0.63) ASIC3PNMTDRD2DRD3CD274
SCHEMBL1010614 0.81 ASIC3 (0.61) ASIC3PNMTDRD2DRD3CD274
SCHEMBL19088736 0.80 ASIC3 (0.60) ASIC3PNMTHTR2AHTR2CHTR2B
SCHEMBL31758844 0.79 ASIC3 (0.63) ASIC3PNMTHTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0687267-B1 PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR MERCK SHARP & DOHME (GB) 1999-09-01 EP disclosed
US-5700809-A Pyrrolo-pyridine derivatives MERCK SHARP & DOHME, LTD. (GB) 1997-12-23 US disclosed
EP-0687267-A1 PYRROLO-PYRIDINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1995-12-20 EP disclosed
WO-1994020459-A2 PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1994-09-15 WO disclosed