Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 6/20 | 0.60 |
| ▸ | PNMT | P11086 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 4/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30534749 | 0.88 | PNMT (0.45) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL8323150 | 0.80 | ASIC3 (0.78) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL532012 | 0.79 | PNMT (0.85) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7807038 | 0.79 | ASIC3 (0.76) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL947776 | 0.78 | PNMT (0.81) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL22391640 | 0.75 | PARP10 (0.68) | CD274 | |
| SCHEMBL30454034 | 0.75 | PARP10 (0.68) | CD274 | |
| SCHEMBL24842524 | 0.75 | CD274 (0.60) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL18554655 | 0.75 | CD274 (0.53) | ASIC3PNMTCD274DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7808608 | 0.74 | ASIC3 (0.97) | ASIC3PNMTHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017117154-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-07-06 | — | — | WO | disclosed |