Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005423 | 0.86 | ALDH1A1 (0.46) | HPGDMAPK1ALDH1A1HSD17B10TP53 | |
| SCHEMBL13634359 | 0.84 | POLB (0.49) | HPGDMAPK1ALDH1A1HSD17B10TP53 | |
| SCHEMBL13162820 | 0.82 | HPGD (0.53) | HPGDMAPK1ALDH1A1HSD17B10TP53 | |
| SCHEMBL12124297 | 0.82 | MEN1 (0.56) | HPGDMAPK1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL25425226 | 0.81 | MEN1 (0.57) | HPGDMAPK1ALDH1A1ALOX15POLB | |
| SCHEMBL13753816 | 0.81 | HPGD (0.49) | HPGDMAPK1ALDH1A1HSD17B10TP53 | |
| SCHEMBL2546081 | 0.80 | ALDH1A1 (0.68) | HPGDMAPK1ALDH1A1HSD17B10TP53 | |
| SCHEMBL30223440 | 0.80 | ALDH1A1 (0.68) | HPGDMAPK1ALDH1A1HSD17B10TP53 | |
| SCHEMBL22066864 | 0.78 | LMNA (0.50) | HPGDMAPK1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL31504981 | 0.77 | HPGD (0.57) | HPGDMAPK1ALDH1A1ALOX15CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929533-A1 | 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME | Du Pont Pharmaceuticals Company (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014436-A1 | 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-04-09 | — | — | WO | disclosed |