Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 6/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.52 |
| ▸ | HTR3B | O95264 | 4/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319125 | 1.00 | HTR3A (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8319559 | 0.85 | KCNH2 (0.62) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8323177 | 0.82 | KCNH2 (0.68) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8323170 | 0.82 | KCNH2 (0.68) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9705203 | 0.81 | HTR3A (0.53) | HTR3ANR4A2 | |
| SCHEMBL8320783 | 0.80 | HTR3A (0.41) | HTR3AKCNH2CYP3A4 | |
| SCHEMBL8323360 | 0.77 | ALDH1A1 (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8323356 | 0.77 | ALDH1A1 (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9471661 | 0.75 | HTR3A (0.71) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL13186221 | 0.75 | HTR3A (0.85) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955470-A | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS, INC. (US) | 1999-09-21 | — | — | US | disclosed |