Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CCR5 | P51681 | 4/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323284 | 1.00 | LMNA (0.57) | LMNAUSP2CCR5PTGER1PTGER4 | |
| SCHEMBL2167875 | 0.90 | PTGER4 (0.67) | LMNAUSP2CCR5PTGER1PTGER4 | |
| SCHEMBL2167870 | 0.90 | PTGER4 (0.67) | LMNAUSP2CCR5PTGER1PTGER4 | |
| SCHEMBL19813850 | 0.87 | CCR5 (0.61) | LMNAUSP2CCR5PTGER1PTGER4 | |
| SCHEMBL27919653 | 0.84 | PTGER4 (0.74) | LMNAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL12018748 | 0.80 | CDK4 (0.71) | LMNAUSP2CCR5PTGER1PTGER4 | |
| SCHEMBL8409659 | 0.80 | CCR5 (0.57) | LMNAUSP2CCR5PTPN1PTP4A3 | |
| SCHEMBL8409657 | 0.80 | CCR5 (0.57) | LMNAUSP2CCR5PTPN1PTP4A3 | |
| SCHEMBL82269 | 0.79 | PTGDR2 (0.61) | LMNAUSP2CCR5PTPN1PTP4A3 | |
| SCHEMBL29690396 | 0.79 | PTGDR2 (0.61) | LMNAUSP2CCR5PTPN1PTP4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |