Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | HTR3A | P46098 | 10/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | HTR3B | O95264 | 1/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.59 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323360 | 1.00 | ALDH1A1 (0.61) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL8323478 | 0.87 | ALDH1A1 (0.66) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL8319139 | 0.83 | ALDH1A1 (0.69) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL8319138 | 0.83 | ALDH1A1 (0.69) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL8320837 | 0.83 | ALDH1A1 (0.69) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL9705203 | 0.82 | HTR3A (0.53) | HTR3A | |
| SCHEMBL8318653 | 0.79 | ALDH1A1 (0.66) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL9680628 | 0.77 | ALDH1A1 (0.76) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL9680622 | 0.77 | ALDH1A1 (0.76) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL7439648 | 0.77 | ALDH1A1 (0.83) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955470-A | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0517984-A1 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0518767-A2 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |