Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607106 | 0.85 | SLC6A4 (0.43) | SLC9A1NR3C2HRH3KDM1ASIRT2 | |
| SCHEMBL4608244 | 0.84 | SIRT2 (0.40) | SLC9A1NR3C2HRH3SIRT2SIRT1 | |
| SCHEMBL3648971 | 0.84 | SMN1; SMN2 (0.48) | SLC9A1NR3C2HRH3KDM1ASIGMAR1 | |
| SCHEMBL4606744 | 0.83 | KDM1A (0.43) | SLC9A1NR3C2KDM1ASLC6A2SLC6A4 | |
| SCHEMBL4606990 | 0.83 | ALDH1A1 (0.49) | KDM1ASIRT2SIRT1SLC6A2SLC6A4 | |
| SCHEMBL4608380 | 0.83 | SIRT2 (0.52) | SLC9A1SIRT2SIRT1 | |
| SCHEMBL4371167 | 0.83 | SLC6A4 (0.43) | HRH3SIRT2SIRT1SLC6A2SLC6A4 | |
| SCHEMBL4371164 | 0.83 | SLC6A4 (0.43) | HRH3SIRT2SIRT1SLC6A2SLC6A4 | |
| SCHEMBL4605333 | 0.83 | HRH3 (0.46) | HRH3KDM1AKCNH2SIRT2SIRT1 | |
| SCHEMBL4606839 | 0.82 | KCNQ3 (0.50) | SLC9A1HRH3KDM1ASIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | claimed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |