Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323795 | 1.00 | MEN1 (0.57) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8322902 | 0.90 | RXRA (0.61) | PTGER1PTGER4PTGER3PTGER2HDAC8 | |
| SCHEMBL8322900 | 0.90 | RXRA (0.61) | PTGER1PTGER4PTGER3PTGER2HDAC8 | |
| SCHEMBL8321304 | 0.89 | LMNA (0.60) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8321308 | 0.89 | LMNA (0.60) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8323817 | 0.89 | MRGPRX4 (0.53) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8323822 | 0.89 | MRGPRX4 (0.53) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8680186 | 0.88 | MEN1 (0.55) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8327237 | 0.88 | MEN1 (0.55) | MEN1KMT2APOLBPKMBLM | |
| SCHEMBL8323676 | 0.88 | KMT2A (0.55) | MEN1KMT2APOLBPKMBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |