Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.64 |
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.64 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CFTR | P13569 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998281 | 0.98 | LMNA (0.94) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL6749604 | 0.88 | LMNA (0.76) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL27016538 | 0.83 | LMNA (0.69) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL10051501 | 0.83 | LMNA (0.69) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL10051500 | 0.83 | LMNA (0.69) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL6274438 | 0.82 | LMNA (0.68) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL14500101 | 0.81 | LMNA (0.66) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL3570145 | 0.80 | LMNA (0.65) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL3564418 | 0.79 | OPRM1 (0.77) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL10038853 | 0.79 | OPRM1 (1.00) | LMNAOPRM1OGFRL1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113336-A1 | CARBOLINE AND BETACARBOLINE DERIVATIVES FOR USE AS HDAC ENZYME INHIBITORS | CHROMA THERAPEUTICS LIMITED (GB) | 2004-12-29 | — | — | WO | disclosed |