Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.64 |
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.64 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CFTR | P13569 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274438 | 0.91 | LMNA (0.68) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL998281 | 0.89 | LMNA (0.94) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL8323918 | 0.88 | LMNA (0.97) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL10051501 | 0.83 | LMNA (0.69) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL10051500 | 0.83 | LMNA (0.69) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL27016538 | 0.83 | LMNA (0.69) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL14500101 | 0.81 | LMNA (0.66) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL3564418 | 0.79 | OPRM1 (0.77) | LMNAOPRM1OGFRL1OPRL1KMT2A | |
| SCHEMBL10038853 | 0.79 | OPRM1 (1.00) | LMNAOPRM1OGFRL1OPRL1 | |
| SCHEMBL517133 | 0.79 | OPRM1 (1.00) | LMNAOPRM1OGFRL1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016775-A1 | ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR | FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD (CN) | 2024-01-18 | — | — | US | disclosed |
| US-20230015617-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2023-01-19 | — | — | US | disclosed |
| US-11160803-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2021-11-02 | — | — | US | disclosed |
| US-10449192-B2 | Phthalazinone derivatives | KUDO PHARMACEUTICALS LIMITED (GB) | 2019-10-22 | — | — | US | disclosed |
| US-20180185363-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2018-07-05 | — | — | US | disclosed |
| US-20170226124-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2017-08-10 | — | — | US | disclosed |
| US-9566276-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2017-02-14 | — | — | US | disclosed |
| US-20110015137-A1 | RECA INHIBITORS AND THEIR USES AS MICROBIAL INHIBITORS OR POTENTIATORS OF ANTIBIOTIC ACTIVITY | TRUSTEES OF BOSTON UNIVERSITY (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2004113336-A1 | CARBOLINE AND BETACARBOLINE DERIVATIVES FOR USE AS HDAC ENZYME INHIBITORS | CHROMA THERAPEUTICS LIMITED (GB) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004058263-A1 | COMPOUND LIBRARIES OF 2, 3, 4, 9-TETRAHYDROSPIRO (BETA-CARBOLINE-1, 4 -PIPERIDINE) DERIVATIVES AND RELATED COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN RECEPTOR | BIOFOCUS PLC (GB) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015137-A1 | RECA INHIBITORS AND THEIR USES AS MICROBIAL INHIBITORS OR POTENTIATORS OF ANTIBIOTIC ACTIVITY | CGAS, RPIA, CLPP | LMNA 1496/4885OPRM1 2863/4885OGFRL1 4240/4885 |
| US-20170226124-A1 | PHTHALAZINONE DERIVATIVES | NR0B1, NR0B2, NR2E1 | LMNA 2988/4885OPRM1 2057/4885OGFRL1 3380/4885 |
| US-10449192-B2 | Phthalazinone derivatives | NR0B1, NR0B2, NR2E1 | LMNA 2854/4885OPRM1 2205/4885OGFRL1 3569/4885 |
| US-11160803-B2 | Phthalazinone derivatives | NR0B1, NR0B2, NR2E1 | LMNA 2854/4885OPRM1 2205/4885OGFRL1 3569/4885 |
| US-20240016775-A1 | ANTI-CORONAVIRUS APPLICATION OF POLY ADP RIBOSE POLYMERASE INHIBITOR | PARP3, PARP1, PARP4 | LMNA 370/4885OPRM1 3967/4885OGFRL1 3688/4885 |
| US-20230015617-A1 | PHTHALAZINONE DERIVATIVES | NR0B1, NR0B2, NR2E1 | LMNA 2988/4885OPRM1 2057/4885OGFRL1 3380/4885 |
| US-20180185363-A1 | PHTHALAZINONE DERIVATIVES | NR0B1, NR0B2, NR2E1 | LMNA 2854/4885OPRM1 2205/4885OGFRL1 3569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.