Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715671 | 0.79 | TDP1 (0.49) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL860791 | 0.79 | KDM4E (0.94) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL798306 | 0.78 | CNR1 (0.33) | KDM4EMAPK1HIF1A | |
| SCHEMBL14590766 | 0.78 | HIF1A (0.65) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL1556426 | 0.78 | EP300 (0.42) | MAPK1TSHRMEN1KMT2A | |
| SCHEMBL204638 | 0.78 | TSHR (0.41) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL9636118 | 0.77 | KDM4E (0.70) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL204637 | 0.77 | KDM4E (0.70) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL19606333 | 0.77 | KDM4E (0.70) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL15743759 | 0.77 | KDM4E (0.70) | KDM4EMAPK1HIF1APAOXADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994342-A | 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |
| WO-1995018807-A1 | NOVEL 3-(SUBSTITUTED METHYL)-4-OXA-1-AZABICYCLO[3.2.0]HEPTAN-7-ONE DERIVATIVES USEFUL AS ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO. LIMITED (JP) | 1995-07-13 | — | — | WO | disclosed |