Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010603 | 0.86 | MRGPRX4 (0.42) | PTGER1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7013840 | 0.84 | PLA2G1B (0.47) | RXRARXRBRXRGMCL1PTGER1 | |
| SCHEMBL7017573 | 0.80 | MEN1 (0.42) | PTGER1MEN1KMT2AALDH1A1SGMS2 | |
| SCHEMBL8318865 | 0.79 | PLA2G1B (0.48) | RXRARXRBRXRGMCL1PTGER1 | |
| SCHEMBL8324082 | 0.77 | PLA2G1B (0.47) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL7013764 | 0.77 | PLA2G1B (0.58) | RXRARXRBRXRGMCL1PTGER1 | |
| SCHEMBL7010577 | 0.74 | HTR1A (0.46) | MEN1KMT2AATP4AATP4BHTR1A | |
| SCHEMBL7015597 | 0.72 | PLA2G1B (0.54) | MEN1KMT2AALDH1A1PLA2G1B | |
| SCHEMBL7007210 | 0.71 | PLA2G1B (0.53) | RXRARXRBRXRGPTGER1PLA2G1B | |
| SCHEMBL7006648 | 0.71 | PLA2G1B (0.44) | PTGER1MEN1KMT2ANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |