Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.33 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8326683 | 0.99 | POLB (0.36) | POLBTHRBEGFRPIK3C3PTK6 | |
| SCHEMBL810355 | 0.88 | PIK3CA (0.40) | POLBTHRBEGFRPIK3C3PTK6 | |
| SCHEMBL8567323 | 0.87 | MAPKAPK2 (0.46) | POLBTHRBEGFRPTK6MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL8330400 | 0.86 | PIK3CA (0.39) | POLBTHRBEGFRPIK3C3PTK6 | |
| SCHEMBL8561272 | 0.84 | GAK (0.37) | POLBTHRBEGFRPIK3C3PTK6 | |
| Hydrochloric Acid SCHEMBL8560744 | 0.83 | GAK (0.36) | POLBTHRBEGFRPIK3C3PTK6 | |
| SCHEMBL8566892 | 0.82 | POLB (0.39) | POLBTHRBEGFRPIK3C3PTK6 | |
| SCHEMBL8559967 | 0.82 | PDGFRA (0.48) | POLBEGFRPTK6MAPTPDGFRA | |
| Hydrochloric Acid SCHEMBL8566059 | 0.81 | HTT (0.50) | POLBEGFRPTK6MAPTPDGFRA | |
| Water SCHEMBL8328226 | 0.81 | PDGFRA (0.47) | POLBEGFRPTK6MAPTPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |