Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 3/20 | 0.42 |
| ▸ | NLK | Q9UBE8 | 3/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8566059 | 0.99 | HTT (0.50) | PDGFRAHTTPDE4BPDE4DFGFR2 | |
| Water SCHEMBL8328226 | 0.99 | PDGFRA (0.47) | PDGFRAHTTPDE4BPDE4DFGFR2 | |
| SCHEMBL8560347 | 0.88 | ERBB2 (0.52) | HTTFGFR2EGFRPOLBRAD52 | |
| SCHEMBL8567323 | 0.87 | MAPKAPK2 (0.46) | PDGFRAEGFRPOLBGAKRIPK2 | |
| Hydrochloric Acid SCHEMBL8566240 | 0.87 | ERBB2 (0.51) | HTTFGFR2EGFRPOLBRAD52 | |
| SCHEMBL8558937 | 0.86 | ADRA1D (0.44) | FGFR2POLBGAKRIPK2COQ8A | |
| SCHEMBL8565860 | 0.86 | POLB (0.54) | PDE4BPDE4DPOLBRAD52RAB9A | |
| Hydrochloric Acid SCHEMBL8561797 | 0.85 | ADRA1D (0.44) | FGFR2POLBGAKRIPK2COQ8A | |
| Hydrochloric Acid SCHEMBL8567040 | 0.85 | LMNA (0.54) | PDE4BPDE4DPOLBRAD52RAB9A | |
| SCHEMBL8327641 | 0.85 | POLB (0.37) | PDGFRAPDE4DEGFRPOLBGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | claimed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | claimed |
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |