Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PLEC | Q15149 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324401 | 0.87 | POLB (0.37) | MAPKAPK2GAAMAPTEGFRPOLB | |
| SCHEMBL8559967 | 0.87 | PDGFRA (0.48) | MAPTEGFRPOLBPTK6PDGFRA | |
| SCHEMBL8561272 | 0.87 | GAK (0.37) | MAPKAPK2GAAMAPTEGFRPOLB | |
| Hydrochloric Acid SCHEMBL8326683 | 0.86 | POLB (0.36) | MAPKAPK2GAAMAPTEGFRPOLB | |
| Hydrochloric Acid SCHEMBL8566059 | 0.86 | HTT (0.50) | MAPTEGFRPOLBPTK6PDGFRA | |
| Water SCHEMBL8328226 | 0.86 | PDGFRA (0.47) | MAPTEGFRPOLBPTK6PDGFRA | |
| Hydrochloric Acid SCHEMBL8560744 | 0.86 | GAK (0.36) | MAPKAPK2GAAMAPTEGFRPOLB | |
| SCHEMBL8327641 | 0.86 | POLB (0.37) | MAPKAPK2EGFRPOLBPTK6PDGFRA | |
| SCHEMBL8566892 | 0.85 | POLB (0.39) | GAAMAPTATMEGFRPOLB | |
| SCHEMBL8560347 | 0.84 | ERBB2 (0.52) | MAPKAPK2GAAMAPTEGFRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |