Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | GAK | O14976 | 3/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.36 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.36 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8561018 | 0.98 | POLB (0.38) | POLBTHRBPTK6EGFRGAK | |
| SCHEMBL8561272 | 0.89 | GAK (0.37) | POLBTHRBPTK6EGFRGAK | |
| Hydrochloric Acid SCHEMBL8560744 | 0.88 | GAK (0.36) | POLBTHRBPTK6EGFRGAK | |
| SCHEMBL8567323 | 0.85 | MAPKAPK2 (0.46) | POLBTHRBPTK6EGFRGAK | |
| SCHEMBL8324401 | 0.82 | POLB (0.37) | POLBTHRBPTK6EGFRGAK | |
| SCHEMBL9541698 | 0.81 | MAPT (0.43) | POLBTHRBMAPTMEN1LMNA | |
| Hydrochloric Acid SCHEMBL8326683 | 0.81 | POLB (0.36) | POLBTHRBPTK6EGFRGAK | |
| SCHEMBL8327641 | 0.81 | POLB (0.37) | POLBTHRBPTK6EGFRGAK | |
| SCHEMBL8559967 | 0.80 | PDGFRA (0.48) | POLBPTK6EGFRGAKSRC | |
| Hydrochloric Acid SCHEMBL8566059 | 0.79 | HTT (0.50) | POLBPTK6EGFRGAKRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |