SCHEMBL8324607

SCHEMBL8324607

COc1ccc(NC(=O)C2CC2)cc1

nearest known ligand 0.74

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.71
MTNR1B P49286 3/20 0.71
HTT P42858 2/20 0.69
NAMPT P43490 1/20 0.66
ACHE P22303 1/20 0.64
BACE1 P56817 1/20 0.64
NPC1 O15118 3/20 0.64
RAB9A P51151 3/20 0.64
POLB P06746 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
ALDH1A1 P00352 1/20 0.62
HPGD P15428 2/20 0.61
NPSR1 Q6W5P4 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30518933 0.94 MTNR1A (0.64) MTNR1AMTNR1BHTTNAMPTACHE
SCHEMBL5205624 0.93 NPC1 (0.69) MTNR1AMTNR1BHTTACHEBACE1
SCHEMBL3197659 0.92 MTNR1A (0.63) MTNR1AMTNR1BHTTNAMPTACHE
SCHEMBL3197669 0.92 MTNR1A (0.63) MTNR1AMTNR1BHTTNAMPTACHE
SCHEMBL3188745 0.92 ENPP3 (0.69) MTNR1AMTNR1BHTTNPC1RAB9A
SCHEMBL8199064 0.89 SMN1; SMN2 (0.64) MTNR1AMTNR1BHTTACHEBACE1
SCHEMBL3210865 0.88 MTNR1A (0.59) MTNR1AMTNR1BHTTNAMPTACHE
SCHEMBL8595938 0.88 MTNR1A (0.59) MTNR1AMTNR1BHTTNAMPTACHE
SCHEMBL8597711 0.88 MTNR1A (0.59) MTNR1AMTNR1BHTTNAMPTACHE
SCHEMBL3210874 0.88 MTNR1A (0.59) MTNR1AMTNR1BHTTNAMPTACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116250545-B Bacillus amyloliquefaciens FCC1256 compositions and methods of controlling plant pathogens FMC公司 2025-05-09 CN disclosed
CN-119950330-A Insect repellent FMC有限公司 2025-05-09 CN disclosed
CN-119855490-A Method for providing control data for an application device 巴斯夫欧洲公司 2025-04-18 CN disclosed
WO-2024076891-A1 POLO LIKE KINASE 4 INHIBITORS ORIC PHARMACEUTICALS, INC. (US) 2024-04-11 WO disclosed
CN-114617136-B Microbial compositions for promoting plant growth and treating plant diseases and methods of use FMC有限公司 2024-03-22 CN disclosed
CN-116456831-A Biological insecticide 坎纳尔地球科学有限公司 2023-07-18 CN disclosed
CN-116250545-A Bacillus amyloliquefaciens FCC1256 compositions and methods of controlling plant pathogens FMC公司 2023-06-13 CN disclosed
CN-107426963-A For agriculture chemistry mixture to be applied to the method and vehicle of field operating area 巴斯夫欧洲公司 2017-12-01 CN disclosed
EP-2556070-B1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES UNIV HEALTH NETWORK (CA) 2017-06-07 EP disclosed
US-8946282-B2 Indolin-2-one derivatives as protein kinase inhibitors Annji Pharmaceutical Co., Ltd. (TW) 2015-02-03 US disclosed
US-20130281451-A1 INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS Annji Pharmaceutical Co., Ltd. (TW) 2013-10-24 US disclosed
EP-1592426-B1 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF NOVARTIS AG (CH) 2007-12-19 EP disclosed
WO-2004069256-A1 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF NOVARTIS AG (CH) 2004-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130281451-A1 INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS ING2, CDK2, MAP3K20 MTNR1A 932/4885MTNR1B 908/4885HTT 2742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.