Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | USP14 | P54578 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL832476 | 1.00 | KMT2A (0.41) | KMT2AL3MBTL1KDM1AMAOBKCNA3 | |
| SCHEMBL833859 | 0.87 | KMT2A (0.42) | KMT2AL3MBTL1KDM1AMAOBKCNA3 | |
| SCHEMBL2489546 | 0.87 | KMT2A (0.42) | KMT2AL3MBTL1KDM1AMAOBKCNA3 | |
| SCHEMBL1900255 | 0.87 | KMT2A (0.42) | KMT2AL3MBTL1KDM1AMAOBKCNA3 | |
| SCHEMBL21754353 | 0.81 | USP14 (0.42) | KMT2AL3MBTL1KDM1AMAOBKCNA3 | |
| SCHEMBL833418 | 0.81 | PTGDR2 (0.58) | KMT2APTGDR2TBXA2RPTGDRABCB11 | |
| SCHEMBL833419 | 0.81 | PTGDR2 (0.58) | KMT2APTGDR2TBXA2RPTGDRABCB11 | |
| SCHEMBL13841442 | 0.78 | PTGDR2 (0.48) | KMT2AL3MBTL1KCNA3DRD2USP14 | |
| SCHEMBL13677409 | 0.78 | PTGDR2 (0.48) | KMT2AL3MBTL1KCNA3DRD2USP14 | |
| SCHEMBL7407022 | 0.76 | HTR6 (0.57) | PTGDR2TBXA2RPTGDRHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143304-B2 | (3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2012-03-27 | — | — | US | disclosed |
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |