Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.42 |
| ▸ | CA1 | P00915 | 9/20 | 0.42 |
| ▸ | CA12 | O43570 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.42 |
| ▸ | CA5A | P35218 | 4/20 | 0.39 |
| ▸ | CA7 | P43166 | 4/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | CA6 | P23280 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670882 | 0.84 | CA2 (0.48) | CA2CA1CA12CA9CA14 | |
| SCHEMBL8324292 | 0.72 | PTAFR (0.37) | NAMPT | |
| SCHEMBL8321977 | 0.72 | NAMPT (0.40) | NAMPTCYP2C9 | |
| SCHEMBL8320444 | 0.71 | PTAFR (0.36) | NAMPTKDM4E | |
| SCHEMBL9672235 | 0.65 | KMT2A (0.45) | CA2CA1CA12CA9CA14 | |
| SCHEMBL1487037 | 0.62 | CA2 (0.57) | CA2CA1CA12CA9CA14 | |
| SCHEMBL9303870 | 0.61 | CA2 (0.47) | CA2CA1CA12CA9CA14 | |
| SCHEMBL29030238 | 0.61 | CA2 (0.64) | CA2CA1CA12CA9CA14 | |
| SCHEMBL635526 | 0.61 | CA2 (1.00) | CA2CA1CA12CA9CA14 | |
| SCHEMBL2475122 | 0.60 | CA2 (0.61) | CA2CA1CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635018-B1 | 4-(1H-2-METHYLIMIDAZO[4,5-c]PYRIDINYLMETHYL)PHENYLSULPHONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF | BRITISH BIO TECHNOLOGY (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0727995-A1 | 4-(1H-2-METHYLIMIDAZO 4,5-C PYRIDINYLMETHYL)PHENYL SULPHONAMIDE CARBOXYLIC ACID DERIVATIVES AS ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| US-5516783-A | PLATELET ACTIVATING FACTOR | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-05-14 | — | — | US | disclosed |
| WO-1995013064-A1 | 4-(1H-2-METHYLIMIDAZO 4,5-C PYRIDINYLMETHYL)PHENYL SULPHONAMIDE CARBOXYLIC ACID DERIVATIVES AS ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |
| WO-1993016075-A1 | 4-(1H-2-METHYLIMIDAZO[4,5-c]PYRIDINYLMETHYL)PHENYLSULPHONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |