Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 7/20 | 0.38 |
| ▸ | CTSB | P07858 | 6/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 5/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326041 | 0.92 | PDCD1 (0.40) | PARP15CTSSCTSBBACE1MAOA | |
| SCHEMBL8323811 | 0.82 | CTSS (0.39) | CTSSCTSBMAOAMAOBCTSL | |
| SCHEMBL8321888 | 0.80 | PARP15 (0.42) | PARP15CTSSCTSBCTSLCTSK | |
| SCHEMBL8324996 | 0.76 | CTSS (0.43) | PARP15CTSSCTSBMAOBCTSL | |
| SCHEMBL8321376 | 0.75 | MAOB (0.45) | TDP1CTSSCTSBMAOAMAOB | |
| SCHEMBL8327208 | 0.74 | MMP1 (0.39) | PARP15CTSSCTSBMAOAMAOB | |
| SCHEMBL8325139 | 0.73 | PARP15 (0.45) | POLBPARP15CTSSCTSBMAOA | |
| SCHEMBL8326543 | 0.73 | LRRK2 (0.36) | CTSSCTSBCTSLCTSKLRRK2 | |
| SCHEMBL8322939 | 0.72 | MAOB (0.44) | PARP15CTSSCTSBMAOAMAOB | |
| SCHEMBL8326572 | 0.71 | MEN1 (0.38) | CTSSCTSBMAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |