Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.34 |
| ▸ | CTSB | P07858 | 5/20 | 0.34 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323811 | 0.81 | CTSS (0.39) | CTSSCTSBCTSLCTSK | |
| SCHEMBL8321888 | 0.81 | PARP15 (0.42) | CTSSCTSBCTSLCTSK | |
| SCHEMBL8326541 | 0.74 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL8324809 | 0.73 | POLB (0.39) | LRRK2CTSSCTSBCTSLCTSK | |
| SCHEMBL8326041 | 0.72 | PDCD1 (0.40) | LRRK2CTSSCTSBCTSLCTSK | |
| SCHEMBL8321008 | 0.67 | GABRG2 (0.35) | CTSSCTSBCTSLCTSK | |
| SCHEMBL11561500 | 0.67 | LRRK2 (0.63) | LRRK2 | |
| SCHEMBL11560468 | 0.67 | MET (0.52) | LRRK2MET | |
| SCHEMBL8324996 | 0.66 | CTSS (0.43) | CTSSCTSBCTSLCTSKGLA | |
| SCHEMBL8675246 | 0.65 | LRRK2 (0.44) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |