Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327429 | 0.84 | TAAR1 (0.42) | MAOATAAR1SIGMAR1SLC18A2SLC6A2 | |
| SCHEMBL8322850 | 0.82 | NFE2L2 (0.45) | TAAR1SIGMAR1SLC18A2CYP2D6MAPT | |
| SCHEMBL8324981 | 0.82 | GRIN1 (0.43) | TAAR1SIGMAR1SLC18A2NPSR1LMNA | |
| SCHEMBL8322028 | 0.81 | TAAR1 (0.44) | MAOATAAR1SIGMAR1SLC18A2SLC6A2 | |
| SCHEMBL8323856 | 0.80 | MAOA (0.49) | MAOAMAOBCYP19A1TAAR1SIGMAR1 | |
| SCHEMBL8326920 | 0.79 | HTR2A (0.46) | SIGMAR1SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL8326976 | 0.77 | MAOB (0.45) | MAOAMAOBCYP19A1TAAR1SIGMAR1 | |
| SCHEMBL8325444 | 0.75 | TAAR1 (0.46) | MAOATAAR1SIGMAR1SLC18A2SLC6A2 | |
| SCHEMBL8324972 | 0.74 | TAAR1 (0.44) | TAAR1SIGMAR1SLC18A2KDM4EMEN1 | |
| SCHEMBL8322029 | 0.73 | CYP3A4 (0.40) | TAAR1SIGMAR1SLC18A2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |