Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 8/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438955 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL14959742 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL1131702 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL2763479 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL82461 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL3802461 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL82462 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL186279 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL17514076 | 0.89 | DPP4 (0.65) | KDM4ELMNAADRA2AADRA2CHIF1A | |
| SCHEMBL6446832 | 0.82 | LMNA (0.55) | KDM4ELMNAADRA2AADRA2CHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981807-A | REACTING A HALO-SUBSTITUTED PHENYLETHANOL WITH PHTHALIC ANHYDRIDE, PERFORMING OPTICAL RESOLUTION ON THE RESULTING COMPOUND USING AN OPTICALLY ACTIVE ORGANIC AMINE AS A RESOLVING AGENT, PERFORMING HYDROLYSIS OR ALCOHOLYSIS | NIHON NOHYAKU CO., LTD. (JP) | 1999-11-09 | — | — | US | disclosed |