Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82461 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL2438955 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL2763479 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL3802461 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL186279 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL17514076 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL14959742 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL1131702 | 1.00 | DPP4 (0.65) | DPP4KDM4EADRA2AADRA2CLMNA | |
| SCHEMBL8120379 | 0.89 | DPP4 (0.52) | DPP4KDM4EADRA2AADRA2CLMNA | |
| Alcohol SCHEMBL8325116 | 0.89 | KDM4E (0.57) | DPP4KDM4EADRA2AADRA2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 399 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117399070-B | Chiral metal synergistic catalytic system containing chelating ligand and application of chiral metal synergistic catalytic system in asymmetric synthesis of bedaquiline | 上海交通大学 | 2025-06-24 | — | — | CN | claimed |
| US-20250083126-A1 | CHIRAL BIMETALLIC COOPERATIVE CATALYSIS SYSTEM CONTAINING CHELATING LIGAND AND USE THEREOF IN ASYMMETRIC SYNTHESIS OF BEDAQUILINE | SHANGHAI JIAO TONG UNIVERSITY (CN) | 2025-03-13 | — | — | US | claimed |
| CN-119552185-A | Method for recycling 4-BMA from 4-BMA mother liquor recycling material by using chiral amine | 济南大学 | 2025-03-04 | — | — | CN | claimed |
| US-12116345-B2 | Low-temperature continuous-flow preparation method of bedaquiline | SHANGHAI JIAOTONG UNIVERSITY (CN) | 2024-10-15 | — | — | US | claimed |
| US-20240308963-A1 | LOW-TEMPERATURE CONTINUOUS-FLOW PREPARATION METHOD OF BEDAQUILINE | SPH NO.1 BIOCHEMICAL & PHARMACEUTICAL CO., LTD. (CN) | 2024-09-19 | — | — | US | claimed |
| CN-117399070-A | Chiral metal synergistic catalytic system containing chelating ligand and application of chiral metal synergistic catalytic system in asymmetric synthesis of bedaquiline | 上海交通大学 | 2024-01-16 | — | — | CN | claimed |
| CN-116899502-A | Method for preparing bedaquiline by low-temperature continuous flow and prepared product | 上海交通大学 | 2023-10-20 | — | — | CN | claimed |
| EP-4247380-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Aclaris Therapeutics, Inc. (US) | 2023-09-27 | — | — | EP | claimed |
| US-11767309-B2 | Methods of synthesizing substituted pyridinone-pyridinyl compounds | ACLARIS THERAPEUTICS, INC. (US) | 2023-09-26 | — | — | US | claimed |
| US-20230286950-A1 | METHODS OF SYNTHESIZING DEUTERATED SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2023-09-14 | — | — | US | claimed |
| US-7820715-B2 | Crystal comprising (2R)-2-propyloctanoic acid and amine | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-10-26 | — | — | US | claimed |
| US-7531657-B2 | Method for preparing sulphostin and analogue thereof or preparation intermediate thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-05-12 | — | — | US | claimed |
| US-20080090907-A1 | Crystal Comprising (2R)-2-Propyloctanoic Acid and Amine | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-04-17 | — | — | US | claimed |
| EP-1741697-A1 | CRYSTAL COMPRISING (2R)-2-PROPYLOCTOIC ACID AND AMINE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-10 | — | — | EP | claimed |
| EP-1387846-B1 | CATALYST FOR ENANTIOSELECTIVE REDUCTION OF KETONES | CENTRE NAT RECH SCIENT (FR) | 2006-03-22 | — | — | EP | claimed |
| US-20060020022-A1 | Enantioselective separation method | PHARMACIA & UPJOHN COMPANY LLC | 2006-01-26 | — | — | US | claimed |
| US-20050020834-A1 | Method for preparation of sulphostin and its analogue or intermediates thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-01-27 | — | — | US | claimed |
| US-6825370-B2 | REACTION OF BORANE AND RANEY NICKEL, COBALT, OR IRON; CYCLIZATION USING AMINOALCOHOL TO PRODUCE OXAZABOROLIDINE | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2004-11-30 | — | — | US | claimed |
| EP-1457494-A1 | PROCESSES FOR PREPARATION OF SULPHOSTIN AND ITS ANALOGUES OR INTERMEDIATES THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2004-09-15 | — | — | EP | claimed |
| US-20040133021-A1 | Catalyst for enantioselective reduction of ketones | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2004-07-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020834-A1 | Method for preparation of sulphostin and its analogue or intermediates thereof | SOST, PTMS, FGF23 | DPP4 987/4885KDM4E 3668/4885ADRA2A 4343/4885 |
| US-20080090907-A1 | Crystal Comprising (2R)-2-Propyloctanoic Acid and Amine | TAS2R5, FFAR2, HRH2 | DPP4 1510/4885KDM4E 2188/4885ADRA2A 43/4885 |
| US-11767309-B2 | Methods of synthesizing substituted pyridinone-pyridinyl compounds | PIR, PUM1, ZRANB2 | DPP4 3244/4885KDM4E 2110/4885ADRA2A 2211/4885 |
| US-20230286950-A1 | METHODS OF SYNTHESIZING DEUTERATED SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | PDXK, DHPS, HCCS | DPP4 3346/4885KDM4E 3331/4885ADRA2A 1197/4885 |
| US-20040133021-A1 | Catalyst for enantioselective reduction of ketones | PDK3, ADH1C, ADH5 | DPP4 4816/4885KDM4E 1099/4885ADRA2A 2490/4885 |
| US-12116345-B2 | Low-temperature continuous-flow preparation method of bedaquiline | NDUFA7, UGT1A7, POLQ | DPP4 4551/4885KDM4E 1922/4885ADRA2A 570/4885 |
| US-20240308963-A1 | LOW-TEMPERATURE CONTINUOUS-FLOW PREPARATION METHOD OF BEDAQUILINE | NDUFA7, UGT1A7, POLQ | DPP4 4551/4885KDM4E 1922/4885ADRA2A 570/4885 |
| US-20060020022-A1 | Enantioselective separation method | SLC7A1, SLC10A1, DHCR7 | DPP4 814/4885KDM4E 4250/4885ADRA2A 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.