Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29797355 | 0.87 | HTT (0.63) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL4822355 | 0.87 | HTT (0.63) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL6409033 | 0.84 | CYP2C9 (0.66) | LMNAMAPK1ALDH1A1MAPTKMT2A | |
| SCHEMBL16908264 | 0.83 | RAB9A (0.47) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL24476677 | 0.82 | HSP90AA1 (0.66) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL28217099 | 0.82 | HTT (0.76) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL8324485 | 0.82 | HTT (0.56) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL12062763 | 0.81 | TAS1R3 (0.49) | TAS1R3TAS1R1ALDH1A1MEN1KMT2A | |
| SCHEMBL503994 | 0.80 | HTT (1.00) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL313217 | 0.80 | LMNA (0.73) | HTTLMNAMAPK1RAB9AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |