Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430169 | 0.81 | CYP19A1 (0.44) | CNR2CYP19A1SLC6A4NFE2L2 | |
| SCHEMBL94275 | 0.80 | HTR2A (0.52) | — | |
| SCHEMBL3903476 | 0.80 | HTR2A (0.64) | IDO1TDO2CNR2CYP19A1SLC6A4 | |
| SCHEMBL23126406 | 0.80 | IDO1 (0.49) | IDO1TDO2CNR2CYP19A1SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL5999540 | 0.78 | IDO1 (0.47) | IDO1TDO2CNR2CYP19A1SLC6A4 | |
| SCHEMBL23021624 | 0.78 | SLC6A2 (0.53) | IDO1TDO2CNR2CYP19A1SLC6A4 | |
| Methylamine SCHEMBL6900406 | 0.77 | IDO1 (0.50) | IDO1TDO2CNR2CYP19A1SLC6A4 | |
| SCHEMBL5999535 | 0.77 | HRH1 (0.67) | IDO1TDO2CNR2CYP19A1SLC6A4 | |
| SCHEMBL8324166 | 0.76 | ACP3 (0.47) | IDO1TDO2SLC6A4SLC6A2AOC3 | |
| SCHEMBL8322755 | 0.76 | KIF11 (0.41) | SLC6A4SLC6A2HDAC4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |