Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8323048 | 0.98 | THRB (0.46) | THRBMAPTTP53GAAPAX8 | |
| SCHEMBL8329028 | 0.91 | THRB (0.38) | THRBMAPTTP53GAAPAX8 | |
| Hydrochloric Acid SCHEMBL8670100 | 0.89 | THRB (0.36) | THRBMAPTTP53GAAPAX8 | |
| SCHEMBL8670121 | 0.80 | MAPT (0.49) | THRBMAPTTP53GAAPAX8 | |
| SCHEMBL8562110 | 0.80 | MAPT (0.56) | THRBMAPTTP53GAA | |
| SCHEMBL8559604 | 0.80 | MAPT (0.62) | THRBMAPTTP53GAAPAX8 | |
| Hydrochloric Acid SCHEMBL8330479 | 0.80 | MAPT (0.48) | THRBMAPTTP53GAAPAX8 | |
| SCHEMBL8564456 | 0.80 | MAPT (0.48) | THRBMAPTTP53GAAPAX8 | |
| SCHEMBL8322260 | 0.80 | DPP4 (0.48) | THRBMAPTDPP4 | |
| Hydrochloric Acid SCHEMBL8566639 | 0.79 | MAPT (0.55) | THRBMAPTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |