Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8670100 | 0.98 | THRB (0.36) | THRBTP53MAPTPAX8EGFR | |
| SCHEMBL8325615 | 0.91 | THRB (0.47) | THRBTP53MAPTPAX8GAA | |
| Hydrochloric Acid SCHEMBL8323048 | 0.89 | THRB (0.46) | THRBTP53MAPTPAX8GAA | |
| SCHEMBL8325619 | 0.83 | THRB (0.31) | THRBMEN1HTTKMT2A | |
| SCHEMBL8324245 | 0.79 | TSHR (0.42) | TP53MAPTKDM4E | |
| SCHEMBL8328843 | 0.78 | MEN1 (0.42) | THRBMAPTPAX8EGFRMEN1 | |
| SCHEMBL8564146 | 0.78 | CSF1R (0.50) | THRBMAPTPAX8EGFRMEN1 | |
| SCHEMBL8329797 | 0.77 | MAPK8 (0.44) | THRBEGFRMEN1HTTKMT2A | |
| SCHEMBL8560369 | 0.76 | MAPT (0.44) | MAPTPAX8KDM4E | |
| SCHEMBL8330039 | 0.75 | MAPT (0.44) | MAPTPAX8EGFRERBB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |