Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 6/20 | 0.46 |
| ▸ | TYMS | P04818 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326393 | 0.89 | TYMS (0.51) | GARTDHFRTYMS | |
| SCHEMBL8318241 | 0.86 | DHFR (0.55) | DHFR | |
| SCHEMBL9067311 | 0.81 | DHFR (0.54) | DHFR | |
| SCHEMBL9067195 | 0.78 | DHFR (0.51) | GARTDHFRTYMS | |
| SCHEMBL9069620 | 0.76 | DHFR (0.53) | DHFRTYMS | |
| SCHEMBL15057071 | 0.76 | DHFR (0.59) | GARTDHFRTYMS | |
| SCHEMBL15057068 | 0.76 | DHFR (0.59) | GARTDHFRTYMS | |
| SCHEMBL8325555 | 0.75 | DHFR (0.54) | GARTDHFRTYMS | |
| SCHEMBL9379640 | 0.74 | TYMS (0.56) | GARTDHFRTYMS | |
| SCHEMBL9379643 | 0.74 | TYMS (0.56) | GARTDHFRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638079-B1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | STANFORD RES INST INT (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5536724-A | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins | SRI INTERNATIONAL (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0638079-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993022312-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1993-11-11 | — | — | WO | disclosed |