Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 7/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325877 | 1.00 | GCK (0.53) | GCKPTGER1SLC6A9PTGER4PTGER3 | |
| SCHEMBL8675421 | 0.83 | GCK (0.54) | GCKPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8675423 | 0.83 | GCK (0.54) | GCKPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8675593 | 0.83 | GCK (0.76) | GCKPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8676537 | 0.83 | PTGER1 (0.59) | GCKPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8676532 | 0.83 | PTGER1 (0.59) | GCKPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8323098 | 0.76 | LMNA (0.54) | GCKPTGER1LMNAALDH1A1KDM4E | |
| SCHEMBL8323106 | 0.76 | LMNA (0.54) | GCKPTGER1LMNAALDH1A1KDM4E | |
| SCHEMBL8161041 | 0.75 | PTGER1 (0.48) | PTGER1LMNAALDH1A1KDM4EPTGDR2 | |
| SCHEMBL8320330 | 0.75 | PTGER4 (0.54) | GCKPTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |