Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.37 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9394927 | 0.90 | CRBN (0.38) | CRBNDDB1OTUD7B | |
| SCHEMBL11066896 | 0.72 | CRBN (0.44) | CRBNDDB1OTUD7B | |
| SCHEMBL22018277 | 0.70 | CRBN (0.47) | CRBNDDB1OTUD7B | |
| SCHEMBL8324983 | 0.68 | CPB2 (0.34) | — | |
| SCHEMBL259592 | 0.68 | CRBN (0.44) | CRBNDDB1OTUD7B | |
| SCHEMBL73966 | 0.67 | TSHR (0.39) | — | |
| Hydrochloric Acid SCHEMBL10916201 | 0.66 | TSHR (0.38) | — | |
| SCHEMBL235218 | 0.65 | CYP2A6 (0.44) | — | |
| SCHEMBL11071163 | 0.63 | TDP2 (0.44) | CRBNDDB1 | |
| SCHEMBL11067414 | 0.61 | ADRA2A (0.54) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |