Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519134 | 0.83 | ATM (0.41) | MEN1KMT2ALMNAATM | |
| SCHEMBL3587635 | 0.81 | POLB (0.41) | MEN1CYP2D6KMT2ALMNASCN1A | |
| SCHEMBL818792 | 0.78 | GBA1 (0.39) | GBA1SLC18A3SIGMAR1MEN1CYP2D6 | |
| SCHEMBL12064486 | 0.76 | HRH3 (0.46) | GBA1SLC18A3SIGMAR1MEN1CYP2D6 | |
| SCHEMBL16655922 | 0.73 | SLC6A4 (0.41) | SIGMAR1MEN1CYP2D6KMT2AITGB3 | |
| SCHEMBL12064519 | 0.73 | SIGMAR1 (0.42) | GBA1SLC18A3SIGMAR1MEN1CYP2D6 | |
| SCHEMBL8655174 | 0.72 | GBA1 (0.47) | GBA1SLC18A3SIGMAR1MEN1CYP2D6 | |
| SCHEMBL16655925 | 0.72 | KMT2A (0.39) | SIGMAR1MEN1CYP2D6KMT2AITGB3 | |
| SCHEMBL817589 | 0.72 | KMT2A (0.37) | GBA1KMT2ASMYD3SLC6A4KCNH2 | |
| SCHEMBL408318 | 0.72 | KMT2A (0.66) | SLC18A3SIGMAR1MEN1CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| EP-0604494-A1 | 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-06 | — | — | EP | disclosed |