Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326304 | 0.81 | KIF11 (0.55) | KIF11PTPN5HDAC4HDAC8KDM4E | |
| SCHEMBL8463022 | 0.81 | KIF11 (0.55) | KIF11PTPN5HDAC4HDAC8KDM4E | |
| SCHEMBL4249887 | 0.80 | TAAR1 (0.46) | ALDH1A1CYP3A4MAPTALOX15TAAR1 | |
| SCHEMBL8324574 | 0.77 | KIF11 (0.46) | KIF11PTPN5TP53CYP3A4ALOX12 | |
| SCHEMBL16191594 | 0.77 | KIF11 (0.53) | KIF11PTPN5RIPK1HDAC4HDAC8 | |
| SCHEMBL8322592 | 0.76 | TSHR (0.46) | KIF11KDM4ETP53CYP3A4MAPT | |
| SCHEMBL8328588 | 0.76 | KIF11 (0.45) | KIF11ALDH1A1ALOX15CHRM3SCN5A | |
| SCHEMBL8324979 | 0.76 | TSHR (0.45) | KIF11ALDH1A1TP53CYP3A4MAPT | |
| SCHEMBL598661 | 0.74 | KIF11 (0.49) | KIF11PTPN5HDAC4HDAC8KDM4E | |
| SCHEMBL4981920 | 0.74 | KIF11 (0.49) | KIF11PTPN5HDAC4HDAC8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |