Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249887 | 0.82 | TAAR1 (0.46) | TSHRTAAR1ALDH1A1ALOX15 | |
| SCHEMBL8327484 | 0.80 | KIF11 (0.40) | KIF11CYP19A1CNR1CNR2TSHR | |
| SCHEMBL8324574 | 0.80 | KIF11 (0.46) | KIF11CNR1CNR2TSHRTAAR1 | |
| SCHEMBL8324979 | 0.79 | TSHR (0.45) | KIF11SIGMAR1TSHRTAAR1ALDH1A1 | |
| SCHEMBL8322592 | 0.79 | TSHR (0.46) | KIF11CYP19A1TSHRTAAR1 | |
| SCHEMBL8324065 | 0.76 | KIF11 (0.50) | KIF11PKMCYP19A1SCN5ASCN9A | |
| SCHEMBL8326388 | 0.76 | KIF11 (0.50) | KIF11SCN5ATAAR1ALDH1A1ALOX15 | |
| SCHEMBL8325767 | 0.73 | KIF11 (0.46) | KIF11TSHRTAAR1ALDH1A1 | |
| SCHEMBL3096971 | 0.72 | CYP19A1 (0.42) | KIF11CYP19A1SCN5ASCN9ATSHR | |
| SCHEMBL78619 | 0.72 | HDAC4 (0.47) | KIF11CYP19A1SCN5ASCN9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1328277-C | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2007-07-25 | — | — | CN | disclosed |
| CN-1246857-A | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |