Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.69 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675593 | 0.91 | GCK (0.76) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL8323106 | 0.86 | LMNA (0.54) | GCKPTGER1LMNAUSP2ALDH1A1 | |
| SCHEMBL8323098 | 0.86 | LMNA (0.54) | GCKPTGER1LMNAUSP2ALDH1A1 | |
| SCHEMBL8320332 | 0.86 | PTGER4 (0.54) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL8320330 | 0.86 | PTGER4 (0.54) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL2642055 | 0.82 | GCK (1.00) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL2642100 | 0.82 | GCK (1.00) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL14519324 | 0.81 | GCK (0.79) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL14519337 | 0.78 | GCK (0.76) | GCKPTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL8323623 | 0.77 | GCK (0.56) | GCKLMNAHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |