Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 5/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326520 | 1.00 | MTNR1B (0.56) | MTNR1BSPHK2SPHK1BRD4PTGER1 | |
| SCHEMBL8675663 | 0.93 | MTNR1B (0.55) | MTNR1BSPHK2SPHK1BRD4PTGER1 | |
| SCHEMBL8321075 | 0.91 | MTNR1B (0.60) | MTNR1BSPHK2SPHK1BRD4PTGER1 | |
| SCHEMBL8675664 | 0.90 | MTNR1B (0.51) | MTNR1BSPHK2SPHK1BRD4PTGER1 | |
| SCHEMBL8324495 | 0.86 | PTGER1 (0.67) | MTNR1BPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8324492 | 0.86 | PTGER1 (0.67) | MTNR1BPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8322870 | 0.85 | PTGER1 (0.55) | MTNR1BPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8324322 | 0.84 | MTNR1B (0.57) | MTNR1BSPHK2SPHK1BRD4PTGER1 | |
| SCHEMBL8678487 | 0.83 | MTNR1B (0.58) | MTNR1BSPHK2SPHK1BRD4PTGER1 | |
| SCHEMBL8322416 | 0.83 | MTNR1B (0.55) | MTNR1BSPHK2SPHK1BRD4PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |