Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327015 | 0.95 | CYP11B2 (0.53) | CYP11B2SCD5SIGMAR1HSD11B1ACACB | |
| SCHEMBL8325258 | 0.89 | CYP11B2 (0.53) | CYP11B2SCD5SIGMAR1HSD11B1ACACB | |
| SCHEMBL615033 | 0.76 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL6715677 | 0.74 | HTR2A (0.53) | SIGMAR1 | |
| SCHEMBL25164880 | 0.72 | CYP3A4 (0.65) | CYP11B2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14240265 | 0.72 | HPGD (0.46) | CYP11B2SCD5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL25052826 | 0.72 | HPGD (0.46) | CYP11B2SCD5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17608988 | 0.71 | CYP2D6 (0.64) | CYP1A2CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL14662248 | 0.71 | CYP11B2 (0.42) | CYP11B2SCD5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16835523 | 0.70 | CYP11B2 (0.40) | CYP11B2SCD5CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |