Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325164 | 0.91 | DRD4 (0.46) | HTR1AHTR7DRD2DRD4KDM4E | |
| SCHEMBL8321866 | 0.87 | DRD2 (0.44) | HTR1AHTR7DRD2DRD4ADRA2A | |
| SCHEMBL8326424 | 0.83 | DRD2 (0.63) | HTR1AHTR7DRD2KDM4EHTR2A | |
| SCHEMBL8324224 | 0.83 | HTR1A (0.49) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL8326374 | 0.80 | DRD2 (0.55) | HTR1ADRD2DRD4KDM4EGFER | |
| SCHEMBL8321611 | 0.78 | DRD2 (0.72) | HTR1ADRD2DRD4KDM4EGFER | |
| SCHEMBL8321133 | 0.71 | DRD2 (0.59) | HTR1ADRD2DRD4ADRA2AADRA2B | |
| SCHEMBL8320719 | 0.70 | DRD2 (0.57) | DRD2DRD4ADRA2AADRA2BSIGMAR1 | |
| SCHEMBL8325505 | 0.69 | DRD2 (0.74) | DRD2DRD4ADRA2AADRA2BSIGMAR1 | |
| SCHEMBL30502286 | 0.68 | DRD2 (0.62) | HTR1AHTR7DRD2DRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594883-B1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NAT SCIENCE COUNCIL (TW) | 1999-01-27 | — | — | EP | disclosed |
| US-5340814-A | Hypotensive agents | NATIONAL SCIENCE COUNCIL (TW) | 1994-08-23 | — | — | US | disclosed |
| EP-0594883-A1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |