Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325164 | 0.85 | DRD4 (0.46) | DRD2ADRA2AADRA2BSIGMAR1HTR2A | |
| SCHEMBL8323168 | 0.83 | CYP3A4 (0.65) | DRD2ADRA2AADRA2BSIGMAR1HTR2C | |
| SCHEMBL8326693 | 0.83 | HTR1A (0.50) | DRD2ADRA2AADRA2BSIGMAR1HTR2A | |
| SCHEMBL8321866 | 0.83 | DRD2 (0.44) | DRD2ADRA2AADRA2BSIGMAR1HTR1A | |
| SCHEMBL8319492 | 0.80 | DRD2 (0.78) | DRD2ADRA2AADRA2BSIGMAR1HTR2C | |
| SCHEMBL9414716 | 0.79 | CYP3A4 (0.72) | DRD2HTR2CHTR2ACYP3A4CYP1A2 | |
| SCHEMBL5674428 | 0.77 | ADRA2A (1.00) | DRD2ADRA2AADRA2BSIGMAR1HTR2C | |
| SCHEMBL29468692 | 0.77 | ADRA2A (1.00) | DRD2ADRA2AADRA2BSIGMAR1HTR2C | |
| SCHEMBL6593239 | 0.77 | ADRA2A (1.00) | DRD2ADRA2AADRA2BSIGMAR1HTR2C | |
| SCHEMBL3400157 | 0.71 | HTR1A (0.58) | DRD2HTR2CHTR2ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594883-B1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NAT SCIENCE COUNCIL (TW) | 1999-01-27 | — | — | EP | claimed |
| EP-0594883-A1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | claimed |
| EP-0594883-B1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NAT SCIENCE COUNCIL (TW) | 1999-01-27 | — | — | EP | disclosed |
| US-5340814-A | Hypotensive agents | NATIONAL SCIENCE COUNCIL (TW) | 1994-08-23 | — | — | US | disclosed |
| EP-0594883-A1 | Imidazo(1,2-c) quinazoline derivatives as antihypertensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |