Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746064 | 0.81 | LMNA (0.49) | SMN1; SMN2TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL6159283 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6158431 | 0.79 | HPGD (0.44) | SMN1; SMN2HPGDTSHRALDH1A1KMT2A | |
| SCHEMBL6157152 | 0.78 | HPGD (0.49) | SMN1; SMN2HPGDTSHRALDH1A1KMT2A | |
| SCHEMBL6159797 | 0.78 | HPGD (0.49) | SMN1; SMN2HPGDTSHRALDH1A1KMT2A | |
| SCHEMBL3562444 | 0.77 | HTR6 (0.53) | SMN1; SMN2TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL952495 | 0.77 | HTR6 (0.53) | SMN1; SMN2TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL952496 | 0.77 | HTR6 (0.53) | SMN1; SMN2TSHRALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL3387782 | 0.77 | CYP2D6 (0.53) | SMN1; SMN2CYP2D6CYP1A2LMNAPKM | |
| SCHEMBL5744572 | 0.77 | CYP2D6 (0.57) | SMN1; SMN2TSHRALDH1A1CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |